What’s Up with That? From yesterday’s New York Times interview with director Darren Aronofsky: As Nancy Friedman tweets, “Aronofsky is from Brooklyn. What’s up with ‘adverts‘?” Share this:EmailFacebookTwitterPrintLike this:Like Loading... Related
This American use of “What’s up with that?” to mean “What’s [all] that about?” really tickles me. In British English, we only use “What’s up with you/her/them?”, etc. to mean “What’s wrong with…?” Reply
notoneoffbritishisms.com 
Aronofsky was married to Rachel Weisz. Perhaps her “Englishness” rubbed off on him?!
This American use of “What’s up with that?” to mean “What’s [all] that about?” really tickles me. In British English, we only use “What’s up with you/her/them?”, etc. to mean “What’s wrong with…?”